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EnvisionTEC 3D Bioplotter bioprinter
The 3D Bioplotter bioprinter system is a rapid prototyping device that can use various biomaterials. It uses 3D CAD models and patient CT scan data to
Product details
3D-Bioplotter ® Biological 3D printer
3D-Bioplotter ® A bioprinting system is a rapid prototyping device that can use multiple biomaterials. It uses 3D CAD models and patient CT scan data to print solid 3D biocompatible structures. The bioprinted models produced have external forms that meet design requirements and internal structures that are open.
3D-Bioplotter®Printing principle
3D-Bioplotter ® The bioprinting system is suitable for the production of biological tissues in sterile environments where biological materials are required, such as using seaweed suspension cells to print biological scaffolds. Compared to other rapid prototyping technologies, 3D Bioplotter ® The system uses a very simple and direct 3D printing technology -3DF technology (Three dimensional fiber deposition). Simply put, the 3D Bioplotter system controls the movement of the printing material cylinder in three-dimensional space, extruding materials that are in a fluid, molten, colloidal, or paste state through air pressure. The materials are stacked layer by layer to form models of different shapes, thus completing the 3D printing process.
Product Features
Can directly use industrial raw materials (such as powdered or granular materials) instead of pre treated wire;
Capable of using medical materials for printing;
A sterile filter specially designed for aseptic requirements, which filters pressurized gases to ensure the biological safety of materials;
The materials are stored in sterile material chambers to avoid direct contact with the machine and ensure that the materials are not contaminated;
Support user-defined printing parameters;
No material control, users can freely choose suppliers, medical material safety grade components, etc., to meet material development needs
Material Requirements
Any material that can be cured through chemical or physical processes can be used as a printing material.
Limitless possibilities
The wide selection of materials provides infinite possibilities for 3D printing.
core features
Import part shape through STL file
Equipped with an automatic print head replacement device, the same printing task supports printing multiple parts and materials
Built in data, fast database, internal network will be filled
Common printing materials have built-in printing parameters to improve the success rate of printing
Independent control of print head temperature throughout the entire printing process
Support 2D point distribution printing
The parameters during the printing process can be controlled through software
5-point temperature curve control
Support low-temperature print heads (0 ℃ -70 ℃) and replaceable PE material raw material warehouses
Support high temperature print heads (room temperature -250 ℃) and steel raw material warehouses
Automatically control the height of the printing table when performing printing tasks in a culture dish
UV curing head 365nm
Print head cleaning: Clean the print head in real-time before and during printing
Screw in needle, with an optional inner diameter ranging from 0.1mm to 1mm
Automatically generate print records after printing is completed, making it easy to retrieve files
3D-Bioplotter®Materials and Applications
Both biotechnology and drug dilution control require 3D biological scaffolds to have good external and internal structures. Currently in 3D Bioplotter ® The biological scaffold made by the system uses the widest range of materials, including polymer melt, gel, ceramics, metals, and so on.
3D-Bioplotter ® Material Overview
Bone regeneration
Hydroxyapatite, Titanium, and Tricalcium Phos phosphate
Drug dilution control
Poly (ε - caprolactone) (PCL), Poly (lactic acid) (PLLA), Lactic acid glycolic acid copolymer (PLGA)
Printing of soft tissue biological structures/organs
Agar, Chitosan, Alginate, Gela tine, Colla gen, Fibrin
conceptual model
Polyurethane, Silicone
3D-Bioplotter ® Material preparation and curing process
1. Post processing sintering: Lingji apatite, triphenyl phosphate, titanium
2. Precipitation: Polyglucosamine, Collagen
3. Dual component structure: alginate, fibrin, polyurethane, silicone
4. Phase transition process from liquid to solid: agar, gelatin, polycaprolactone, lactic acid glycolic acid copolymer, polylactic acid
3D-Bioplotter ® The system uses the latest 3DF technology (three-dimensional fiber deposition technology), developed by Envision, a professional manufacturer of rapid prototyping and rapid manufacturing equipment in Germany. In the field of tissue engineering, an important issue is that the structure and mechanical properties of implants and scaffolds can be similar to those of regenerated human organs, while traditional manufacturing techniques are difficult to control the mechanical structure and properties of scaffolds. The new type of biological scaffold manufactured using 3DF technology (three-dimensional fiber deposition technology) has shown great potential in tissue engineering applications, specifically reflecting the precision of repeated production, biocompatibility, and porous structure that is not affected by shape and size, and all internal pores are 100% identical.
Drug controlled release
CONTROLLED RELEASE OF DRUGS
Cell and organ printing
CELL AND ORGAN PRINT
bone tissue engineering
BONE TISSUE ENGINEERING
scientific research achievements
ACHIEVEMENTS IN SCIENTIFIC RESEARCH
Currently, using 3D Bioplotter ® The scientific research based on bioprinters has achieved rich results, which not only provides strong theoretical support for the application of 3D bioprinting, but also provides new research ideas for the development of materials science and life sciences. As of April 2017, as many as 189 papers have been published, with high quality. The published journals mainly include The Lancet（IF=44.002）、Advanced Functional Materials（IF=11.382）、Biomaterials（IF=8.387） Waiting for top tier journals.
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