The production of antibiotics, vitamins, and amino acids in the pharmaceutical industry mainly adopts the biological fermentation method using grains as the main raw material. The concentration of the target product in the fermentation broth is very low, generally only accounting for 0 About 1% -5%, and containing a large amount of other impurities such as mycelium, proteins, residual soluble substrates, intermediate metabolitesFermentation broth pretreatmentSubstances added during the process; Moreover, some target products have poor heat resistance, pH resistance, and organic solvent resistance. Therefore, to remove a large amount of impurities from the fermentation broth and produce high-purity products that comply with pharmacopoeia regulations, extraction and refining are important steps.

Choosing an appropriate membrane separation process can replace various traditional separation and concentration methods such as vacuum hub filtration, plate and frame filtration, centrifugal separation, flocculation, ion exchange, solvent extraction, evaporation, etc. Membrane separation technology has become one of the important means to achieve product separation in the fermentation pharmaceutical industry.

The process characteristic of bidirectional flow is that the same hollow fiber membrane module is in both working and cleaning states during the filtration process, thereby maintaining high separation efficiency. This process is particularly suitable for filtering and refining viscous liquids such as fermentation broth, changing the previous situation where hollow fiber membranes could not be used for filtering and separating viscous liquids, and expanding the application fields of hollow fiber membranes. It has the advantages of small equipment footprint, low cost, and high recovery rate of concentrated liquid, especially suitable for large-scale fermentation broth treatment.

Chengdu Zhongzhi Filtration Technology Co., Ltd. has conducted extensive experimental research on the application of membrane technology in the post-treatment process of fermentation broth, some of which have been industrialized. Its research and application work mainly focuses on antibiotics, vitamins, amino acids, enzyme preparations, and other aspects.

Our self-developed membrane system, including software and hardware, provides solutions for customers in different industriesMembrane Separation Purification and Clean ProductionComprehensive solutions for related process engineering.

Application fields:

1. Antibiotics (cephalosporins, streptococci, penicillins, erythromycin, etc.)

2. Organic acids (lysine, glutamic acid, L-lactic acid citric acid, ribonucleic acid, succinic acid, tryptophan, threonine, glutamic acid, citric acid, clavulanic acid, lactic acid, amino acids, etc.)

3. Fermentation and enzymatic hydrolysis of peptide substances (such as mannan peptides, protein peptides, etc.);

4. Pharmaceutical intermediates (VC, erythromycin, penicillin, cephalosporin, oxytetracycline, streptomycin, vancomycin, inositol, etc.);

5. Enzyme preparations (glucose isomerase, alpha amylase, cellulase, pectinase, protease, etc.);

6. Concentrate live bacteria (such as lactic acid bacteria, Escherichia coli, etc.).