The fermentation industry is a rapidly emerging industry that emerged in the second half of the 20th century. It is basically an industry that uses grain as the main raw material and produces products through microbial fermentation. The fermentation industry is a new growth point for the development of China's light industry, and membrane separation is one of the key technologies for the technological transformation of the fermentation industry. The main methods for separating and refining fermentation products include precipitation, salting out, solvent extraction, adsorption, etc. In addition to these main separation processes, it is also necessary to supplement them with bacterial separation, concentration, decolorization, crystallization, and other processes. In order to improve product quality, reduce costs, increase yield, and shorten processing time, further research and improvement are needed on existing post-treatment processes and methods. In addition, with the rapid development of biotechnology, new products continue to emerge, obtaining a variety of structurally complex substances that were previously unavailable. The purity requirements for new products have correspondingly increased, which puts new demands on the post-processing process.

Membrane concentration technologyAs a new type of separation technology, it has many advantages:

(1) High degree of automation, using PLC and frequency converter control, simple and convenient operation;

(2) The operating cost of membrane systems is low, which is 1/5 of traditional processes;
(3) During the membrane concentration process of the alcohol extract, the loss of ethanol is less than 1%;
(4) The thorough removal of impurities by the membrane effectively improves the efficiency of subsequent processes and enhances product purity;
(5) Membrane concentration effluent can be deeply treated for reuse or discharge, reducing environmental pressure;
(6) The high-temperature concentration process damages the thermosensitive active ingredients and reduces the yield
The membrane concentration process is coherent, reducing the volume of thermal concentration, decreasing the investment in equipment such as tanks, shortening the thermal concentration time, saving steam consumption, improving production efficiency, and increasing product yield

Chengdu Zhongzhi Filtration Technology Co., Ltd. has conducted extensive experimental research on the application of membrane technology in the post-treatment process of fermentation broth, some of which have been industrialized. Its research and application work mainly focuses on antibiotics, vitamins, amino acids, enzyme preparations, and other aspects. The self-developed membrane system, including software and hardware, provides comprehensive process engineering solutions related to membrane separation, purification, and clean production for customers in different industries.

Application fields:

1. Antibiotics (cephalosporins, streptococci, penicillins, erythromycin, etc.)

2. Organic acids (lysine, glutamic acid, L-lactic acid citric acid, ribonucleic acid, succinic acid, tryptophan, threonine, glutamic acid, citric acid, clavulanic acid, lactic acid, amino acids, etc.)

3. Fermentation and enzymatic hydrolysis of peptide substances (such as mannan peptides, protein peptides, etc.);

4. Pharmaceutical intermediates (VC, erythromycin, penicillin, cephalosporin, oxytetracycline, streptomycin, vancomycin, inositol, etc.);

5. Enzyme preparations (glucose isomerase, alpha amylase, cellulase, pectinase, protease, etc.);

6. Concentrate live bacteria (such as lactic acid bacteria, Escherichia coli, etc.).